In Basecamp, using different route profile settings causes routes to calculate differently. If you have customized the profiles, that virtually guarantees calculation differences. Best to keep it simple and use the most common standard profiles.
When I scrubbed the road routes, I used the Automobile driving profile. For ADV routes, I used the Dirt Biking profile.
Many people try to use the Motorcycling profile because "that's what I'm doing!" You will have a very difficult time getting routes to calculate properly because the Motorcycling profile avoidances include
Interstate highways
Major highways
Mapset used was City Navigator North America NT 2019.1
Norm Kern